Diabetes, Inflammation, Proinflammatory Cytokines, and Diabetic Nephropathy
نویسندگان
چکیده
منابع مشابه
Inflammatory Cytokines in Diabetic Nephropathy
Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy, which is the largest single cause of end-stage renal disease and a medical catastrophe of worldwide dimensions. Metabolic and hemodynamic alterations have been considered as the classical factors involved in the development of renal injury in patients with diabetes mellitus. However, the exact pathogenic m...
متن کاملInflammation in Diabetic Nephropathy
Diabetic nephropathy is the leading cause of end-stage kidney disease worldwide but current treatments remain suboptimal. This review examines the evidence for inflammation in the development and progression of diabetic nephropathy in both experimental and human diabetes, and provides an update on recent novel experimental approaches targeting inflammation and the lessons we have learned from t...
متن کاملInflammation and the pathogenesis of diabetic nephropathy.
The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic nephropathy on the increasing population with CKD (chronic kidney disease) and ESRD is enormous. Three major pathways showing abnormality of intracellular metabolism have been identified in the development of diabetic neph...
متن کاملDiabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis
1Department of Cardiovascular andThoracic Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY 40202, USA 2Department of Medicine and Division of Nephrology and Hypertension, School of Medicine, University of Louisville, Louisville, KY 40202, USA 3Department of Nephrology, The Second Hospital and Advanced Institute for Medical Sciences, Dalian Medical Universit...
متن کاملDiabetic nephropathy, inflammation, hyaluronan and interstitial fibrosis.
Hyaluronan (HA) is a ubiquitous connective tissue glycosaminoglycan component of most extracellular matrices and alterations in its synthesis have been suggested to be involved in the glomerular changes of diabetic nephropathy. Similarly it has been suggested that macrophages are involved in the initiation of diabetic glomerular injury. Much less is known regarding the role of the prognostic va...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2006
ISSN: 1537-744X
DOI: 10.1100/tsw.2006.179